Dabrafenib (Tafinlar)

Dabrafenib (Tafinlar) is a first line treatment for patients with BRAF V600 mutation-positive unresectable stage IIIC or IV melanoma or metastatic melanoma. About half of all melanoma skin cancers make too much BRAF due to a change in a gene. Dabrafenib acts as an inhibitor of the BRAF protein and slows down or stops the growth of cancer cells. The drug is administered as a pill taken daily.

Side Effects

The most common side effects from Tafinlar included thickening of the skin, non-cancerous skin tumors, headache, fever, joint pain, hair loss, and hand-foot syndrome. Less common, but more serious side effects included an increased risk of another type of skin cancer (squamous cell carcinoma); fever complicated by low blood pressure, shaking chills, dehydration, and kidney failure; eye problems; and increased blood sugar levels.

Always talk to your doctor, pharmacist or nurse about your side effects so they can help you manage them.

Reference: https://www.cancer.org/latest-news/fda-approves-2-new-melanoma-drugs.html

Provincial Funding Summary

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Dabrafenib (Tafinlar) for Metastatic Melanoma (pCODR 10025)
This information is current as of July 20,2020

Note: Funding criteria as listed on the decision date. Please refer to the provincial drug programs for the most recent funding criteria and program eligibility.

Click Here to visit CADTH pan-Canadian Oncology Drug Review

Please note: This information is not meant to act as a treatment decision aid, but rather to provide general information about which metastatic melanoma or skin cancer treatments are covered by provincial health care plans in Canada. It is current to the date indicated and may not be currently accurate due to the changing landscape of coverage in Canada. If you have private insurance coverage, you may have access to therapies not covered by the provincial plans in your province.  All information obtained about specific treatments should be further discussed with your physician.

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