cobimetinib (Cotellic) + vemurafenib (Zelboraf)

TARGET THERAPIES

About Targeted Therapies


cobimetinib (Cotellic) + vemurafenib (Zelboraf)


debrafenib (Tafinlar) + trametinib (Mekinist)

cobimetinib (Cotellic) + vemurafenib (Zelboraf)

COTELLIC is a prescription medicine that is used with the medicine ZELBORAF, to treat melanoma:

  • Vemurafenib blocks the activity of a mutated form of a molecule called BRAF. Cobimetinib blocks the activity of a molecule called MEK. BRAF and MEK are protein molecules that are important in regulating cell growth.The BRAF V600E and V600K mutations signal cells to grow abnormally and divide out of control. These cells can become a melanoma tumor. About half of all melanomas have a BRAF mutation. MEK receives signals from BRAF and other molecules in the cell. In melanoma treatment, researchers have found that blocking BRAF and MEK at the same time is more effective than blocking MEK alone.The combination of vemurafenib and cobimetinib interferes with abnormal BRAF signals to slow or stop the out-of-control cell growth:
    • Vemurafenib blocks the signaling pathway of the V600E-mutated BRAF molecule.
    • Cobimetinib blocks signaling from the V600E- or V600K-mutated BRAF molecule via the MEK molecule.
  • for more information visit Roche Canada

Side Effects

The most common side effects of COTELLIC in combination with ZELBORAF include:

  • diarrhea
  • nausea
  • fever
  • vomiting
  • sunburn or sun sensitivity

Always talk to your doctor, pharmacist or nurse about your side effects so they can help you manage them.

Provincial Funding Summary

Cobimetinib (Cotellic) for Metastatic Melanoma (pCODR 10070) Click Here to visit CADTH pan-Canadian Oncology Drug Review
This information is current as of November 9, 2018.
Note: Funding criteria as listed on the decision date. Please refer to the provincial drug programs for the most recent funding criteria and program eligibility.

Please note: This information is not meant to act as a treatment decision aid, but rather to provide general information about which metastatic melanoma or skin cancer treatments are covered by provincial health care plans in Canada. It is current to the date indicated and may not be currently accurate due to the changing landscape of coverage in Canada. If you have private insurance coverage, you may have access to therapies not covered by the provincial plans in your province.  All information obtained about specific treatments should be further discussed with your physician.

Melanoma What You Need To Know

A leading national melanoma resource written with the help of specialists in oncology and health care.

Watch Now Melanoma Updates and Treatments

Melanoma Support

The Melanoma Network of Canada has a number of free services for patients, caregivers and healthcare professionals.

Menu